SLC7A4

Entrez Summary: N/A
UniProt Summary: Involved in the transport of the cationic amino acids (arginine, lysine and ornithine).

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Rotenone 20μM R00 exp34	-1.81
Actinomycin-D 0.001μM R00 exp3	-1.72

basic amino acid transmembrane transporter activity
basic amino acid transmembrane transport
basic amino acid transport
amino acid transmembrane transport
amino acid transport
carboxylic acid transmembrane transport
organic acid transmembrane transport
anion transmembrane transport
organic acid transport
carboxylic acid transport
cellular amino acid metabolic process
organic anion transport
anion transport
carboxylic acid metabolic process
ion transmembrane transport
oxoacid metabolic process
organic acid metabolic process
transmembrane transport
ion transport
small molecule metabolic process
nitrogen compound transport