SLC9A6

Entrez Summary: This gene encodes a sodium-hydrogen exchanger that is amember of the solute carrier family 9. The encoded protein localizes to early and recycling endosomes and may be involved in regulating endosomal pH and volume. Defects in this gene are associated with X-linked syndromic cognitive disability, Christianson type. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

axonal spine
brain-derived neurotrophic factor receptor signaling pathway
dendrite extension
potassium:proton antiporter activity
sodium:proton antiporter activity
regulation of neurotrophin TRK receptor signaling pathway
sodium ion import across plasma membrane
dendritic spine development
axon extension
axon terminus
neuron projection extension
inorganic ion import across plasma membrane
inorganic cation import across plasma membrane
recycling endosome membrane
regulation of intracellular pH
developmental cell growth
sodium ion transmembrane transport
cell growth
regulation of cellular pH
import across plasma membrane
regulation of pH
dendrite development
cellular monovalent inorganic cation homeostasis
developmental growth involved in morphogenesis
recycling endosome
late endosome
monovalent inorganic cation homeostasis
proton transmembrane transport
early endosome membrane
sodium ion transport
potassium ion transmembrane transport
potassium ion transport
synapse organization
regulation of cellular response to growth factor stimulus
anion transmembrane transport
axonogenesis
developmental growth
growth
monovalent inorganic cation transport
axon development