SMPDL3A

Entrez Summary: N/A
UniProt Summary: Has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP (PubMed:25288789, PubMed:26783088). Has in vitro activity with p-nitrophenyl-TMP (PubMed:25288789). Has lower activity with nucleoside diphosphates, and no activity with nucleoside monophosphates (PubMed:25288789, PubMed:26783088). Has in vitro activity with CDP-choline, giving rise to CMP and phosphocholine. Has in vitro activity with CDP-ethanolamine (PubMed:26783088). Does not have sphingomyelin phosphodiesterase activity (PubMed:25288789, PubMed:26783088). {ECO:0000269|PubMed:25288789, ECO:0000269|PubMed:26783088}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

sphingomyelin catabolic process
sphingomyelin phosphodiesterase activity
phosphoric diester hydrolase activity
nucleoside triphosphate catabolic process
sphingomyelin metabolic process
sphingolipid catabolic process
membrane lipid catabolic process
phospholipid catabolic process
nucleoside phosphate catabolic process
nucleoside triphosphate metabolic process
nucleobase-containing small molecule biosynthetic process
organophosphate catabolic process
sphingolipid metabolic process
ammonium ion metabolic process
cellular lipid catabolic process
membrane lipid metabolic process
lipid catabolic process
nucleobase-containing compound catabolic process
phospholipid metabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
nucleoside phosphate metabolic process
organic cyclic compound catabolic process
nucleobase-containing small molecule metabolic process
small molecule biosynthetic process
cellular amide metabolic process
zinc ion binding
organophosphate metabolic process
cellular lipid metabolic process
organonitrogen compound catabolic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
lipid metabolic process
organic cyclic compound biosynthetic process
extracellular space
cellular nitrogen compound biosynthetic process
small molecule metabolic process
organic substance catabolic process