SMURF2

Gene Information

Official Symbol: SMURF2
Official Name: SMAD specific E3 ubiquitin protein ligase 2
Aliases and Previous Symbols: N/A
Entrez ID: 64750
UniProt: Q9HAU4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level. {ECO:0000269|PubMed:11389444, ECO:0000269|PubMed:12717440}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17230
Expression level (log2 read counts): 4.98

Expression Distribution

Screen	Score
Mitomycin-C 0.06μM R08 exp503	-1.76
Beta-Estradiol 0.55μM R07 exp425	-1.73
Nocodazole 0.1μM R03 exp94	1.77
Hippuristanol 0.12μM R08 exp488	1.8

C2
WW
HECT

ubiquitin-dependent SMAD protein catabolic process
positive regulation of trophoblast cell migration
regulation of trophoblast cell migration
transforming growth factor beta receptor binding
negative regulation of BMP signaling pathway
SMAD binding
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of cellular response to transforming growth factor beta stimulus
positive regulation of reproductive process
regulation of BMP signaling pathway
BMP signaling pathway
Wnt signaling pathway, planar cell polarity pathway
cellular response to BMP stimulus
response to BMP
ubiquitin ligase complex
regulation of establishment of planar polarity
regulation of transforming growth factor beta receptor signaling pathway
regulation of cellular response to transforming growth factor beta stimulus
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
non-canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
negative regulation of cellular response to growth factor stimulus
regulation of reproductive process
positive regulation of Wnt signaling pathway
regulation of morphogenesis of an epithelium
transmembrane receptor protein serine/threonine kinase signaling pathway
positive regulation of protein catabolic process
ubiquitin protein ligase activity
membrane raft
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
ubiquitin-protein transferase activity
regulation of animal organ morphogenesis
regulation of cellular response to growth factor stimulus
protein deubiquitination
regulation of canonical Wnt signaling pathway
protein modification by small protein removal
protein polyubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
Wnt signaling pathway