SMYD2

Entrez Summary: N/A
UniProt Summary: Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'. {ECO:0000269|PubMed:17108971, ECO:0000269|PubMed:17805299, ECO:0000269|PubMed:18065756, ECO:0000269|PubMed:20870719, ECO:0000269|PubMed:21782458, ECO:0000269|PubMed:21880715}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

SET
zf-MYND

lysine N-methyltransferase activity
histone H3-K36 methylation
histone methyltransferase activity (H3-K36 specific)
peptidyl-lysine monomethylation
peptidyl-lysine dimethylation
protein-lysine N-methyltransferase activity
RNA polymerase II complex binding
regulation of DNA damage response, signal transduction by p53 class mediator
p53 binding
histone lysine methylation
peptidyl-lysine methylation
histone methylation
protein methylation
protein alkylation
regulation of signal transduction by p53 class mediator
regulation of response to DNA damage stimulus
macromolecule methylation
methylation
peptidyl-lysine modification
histone modification
covalent chromatin modification
heart development
negative regulation of cell population proliferation
chromatin organization
regulation of cellular response to stress
negative regulation of transcription by RNA polymerase II
circulatory system development
peptidyl-amino acid modification
chromosome organization
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
regulation of response to stress
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
regulation of cell population proliferation