SNCAIP

Entrez Summary: This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Ank
Ank 2

regulation of inclusion body assembly
dopamine metabolic process
catecholamine metabolic process
catechol-containing compound metabolic process
cytoplasmic ribonucleoprotein granule
presynaptic membrane
phenol-containing compound metabolic process
regulation of neurotransmitter secretion
synaptic vesicle
regulation of neurotransmitter transport
ammonium ion metabolic process
ubiquitin protein ligase binding
regulation of neurotransmitter levels
neuronal cell body
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
organic hydroxy compound metabolic process
drug metabolic process
regulation of secretion by cell
regulation of secretion
regulation of cellular localization
regulation of cellular component biogenesis
identical protein binding
cell death
regulation of transport