SNX5

Gene Information

Official Symbol: SNX5
Official Name: sorting nexin 5
Aliases and Previous Symbols: N/A
Entrez ID: 27131
UniProt: Q9Y5X3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:15561769). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:17148574, PubMed:18596235). May function as link between endosomal transport vesicles and dynactin (Probable). Plays a role in the internalization of EGFR after EGF stimulation (Probable). Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C isoform 3 and is retromer-independent (PubMed:23602387). Together with PIP5K1C isoform 3 facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation (Probable). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). Plays a role in macropinocytosis (PubMed:18854019, PubMed:21048941). {ECO:0000269|PubMed:18854019, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:24610942, ECO:0000303|PubMed:15561769, ECO:0000303|PubMed:19619496, ECO:0000303|PubMed:23085988}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17649
Expression level (log2 read counts): 8.33

Expression Distribution

Screen	Score
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-1.76
35°C R06 exp302	-1.72

PX
Vps5

macropinocytic cup
epidermal growth factor catabolic process
retromer, tubulation complex
tubular endosome
extrinsic component of endosome membrane
D1 dopamine receptor binding
pinocytosis
dynactin binding
positive regulation of renal sodium excretion
phosphatidylinositol-5-phosphate binding
retromer complex
regulation of renal sodium excretion
regulation of excretion
phagocytic cup
phosphatidylinositol-3,5-bisphosphate binding
phosphatidylinositol-4-phosphate binding
regulation of renal system process
negative regulation of blood pressure
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of ERBB signaling pathway
brush border
extrinsic component of cytoplasmic side of plasma membrane
regulation of epidermal growth factor receptor signaling pathway
phosphatidylinositol binding
regulation of ERBB signaling pathway
ruffle
retrograde transport, endosome to Golgi
cytoplasmic vesicle membrane
cytosolic transport
early endosome membrane
regulation of macroautophagy
regulation of blood pressure
endosomal transport
endosome
cadherin binding
regulation of autophagy
blood circulation
circulatory system process
positive regulation of secretion
protein heterodimerization activity