SOX15 [The Human Chemical-Genetic Interaction Map Project]

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======= SOX15 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SOX15
  * **<color #00a2e8>Official Name</color>**: SRY-box transcription factor 15
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6665|6665]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60248|O60248]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SOX15&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SOX15|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601297|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to the 5'-AACAAT-3' sequence.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HMG box|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|myoblast development|
|positive regulation of satellite cell activation involved in skeletal muscle regeneration|
|regulation of satellite cell activation involved in skeletal muscle regeneration|
|positive regulation of G0 to G1 transition|
|positive regulation of skeletal muscle tissue regeneration|
|positive regulation of myoblast proliferation|
|regulation of skeletal muscle tissue regeneration|
|regulation of myoblast proliferation|
|nuclear transcription factor complex|
|skeletal muscle tissue regeneration|
|myoblast differentiation|
|regulation of G0 to G1 transition|
|negative regulation of striated muscle tissue development|
|negative regulation of muscle organ development|
|negative regulation of muscle tissue development|
|positive regulation of wound healing|
|tissue regeneration|
|positive regulation of response to wounding|
|regulation of striated muscle tissue development|
|male gonad development|
|regulation of muscle tissue development|
|development of primary male sexual characteristics|
|regulation of muscle organ development|
|regulation of wound healing|
|regeneration|
|male sex differentiation|
|regulation of response to wounding|
|positive regulation of developmental growth|
|gonad development|
|development of primary sexual characteristics|
|positive regulation of growth|
|sex differentiation|
|positive regulation of cell cycle process|
|regulation of developmental growth|
|positive regulation of cell cycle|
|developmental growth|
|growth|
|chromatin binding|
|positive regulation of cell activation|
|reproductive structure development|
|reproductive system development|
|muscle structure development|
|wound healing|
|protein heterodimerization activity|
|response to wounding|
|regulation of cell activation|
|developmental process involved in reproduction|
|regulation of growth|
|DNA-binding transcription factor activity|
|chromatin organization|
|regulation of cell cycle process|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of cell population proliferation|
|negative regulation of developmental process|
|central nervous system development|
|neuron differentiation|
|chromosome organization|
|regulation of response to external stimulus|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10269
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SOX15 Expression in NALM6 Cells: 0.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>