SOX15
Gene Information
- Official Symbol: SOX15
- Official Name: SRY-box transcription factor 15
- Aliases and Previous Symbols: N/A
- Entrez ID: 6665
- UniProt: O60248
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Binds to the 5'-AACAAT-3' sequence.
Pfam Domains GO Terms
Pfam Domains
| HMG box |
GO Terms
| myoblast development |
| positive regulation of satellite cell activation involved in skeletal muscle regeneration |
| regulation of satellite cell activation involved in skeletal muscle regeneration |
| positive regulation of G0 to G1 transition |
| positive regulation of skeletal muscle tissue regeneration |
| positive regulation of myoblast proliferation |
| regulation of skeletal muscle tissue regeneration |
| regulation of myoblast proliferation |
| nuclear transcription factor complex |
| skeletal muscle tissue regeneration |
| myoblast differentiation |
| regulation of G0 to G1 transition |
| negative regulation of striated muscle tissue development |
| negative regulation of muscle organ development |
| negative regulation of muscle tissue development |
| positive regulation of wound healing |
| tissue regeneration |
| positive regulation of response to wounding |
| regulation of striated muscle tissue development |
| male gonad development |
| regulation of muscle tissue development |
| development of primary male sexual characteristics |
| regulation of muscle organ development |
| regulation of wound healing |
| regeneration |
| male sex differentiation |
| regulation of response to wounding |
| positive regulation of developmental growth |
| gonad development |
| development of primary sexual characteristics |
| positive regulation of growth |
| sex differentiation |
| positive regulation of cell cycle process |
| regulation of developmental growth |
| positive regulation of cell cycle |
| developmental growth |
| growth |
| chromatin binding |
| positive regulation of cell activation |
| reproductive structure development |
| reproductive system development |
| muscle structure development |
| wound healing |
| protein heterodimerization activity |
| response to wounding |
| regulation of cell activation |
| developmental process involved in reproduction |
| regulation of growth |
| DNA-binding transcription factor activity |
| chromatin organization |
| regulation of cell cycle process |
| negative regulation of transcription by RNA polymerase II |
| positive regulation of cell population proliferation |
| negative regulation of developmental process |
| central nervous system development |
| neuron differentiation |
| chromosome organization |
| regulation of response to external stimulus |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| negative regulation of nucleobase-containing compound metabolic process |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of cell population proliferation |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| tissue development |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Quinacrine 2.5μM R03 exp146 | -1.79 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10269
- Expression level (log2 read counts): 0.96
Expression Distribution
SOX15 Expression in NALM6 Cells: 0.96
