SPAG16

Entrez Summary: N/A
UniProt Summary: Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

axonemal central apparatus
sperm axoneme assembly
sperm flagellum
axoneme assembly
flagellated sperm motility
sperm motility
microtubule bundle formation
cilium or flagellum-dependent cell motility
cilium-dependent cell motility
axoneme
spermatid development
spermatid differentiation
germ cell development
cilium assembly
cellular process involved in reproduction in multicellular organism
cilium organization
plasma membrane bounded cell projection assembly
cell projection assembly
microtubule cytoskeleton organization
spermatogenesis
male gamete generation
developmental process involved in reproduction
microtubule-based process
gamete generation
organelle assembly
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
multi-organism reproductive process
localization of cell
cell motility
cytoskeleton organization
plasma membrane bounded cell projection organization
cell projection organization
locomotion
reproductive process
reproduction
movement of cell or subcellular component
cell development