SPDEF

Gene Information

Official Symbol: SPDEF
Official Name: SAM pointed domain containing ETS transcription factor
Aliases and Previous Symbols: N/A
Entrez ID: 25803
UniProt: O95238
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT- 3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter. {ECO:0000269|PubMed:10625666}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	2/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8253
Expression level (log2 read counts): -6.6

Expression Distribution

Ets
SAM PNT

lung goblet cell differentiation
lobar bronchus epithelium development
lobar bronchus development
positive regulation of cell fate commitment
lung secretory cell differentiation
bronchus development
intestinal epithelial cell development
negative regulation of cell fate commitment
intestinal epithelial cell differentiation
lung epithelial cell differentiation
lung cell differentiation
regulation of cell fate commitment
lung epithelium development
glandular epithelial cell differentiation
columnar/cuboidal epithelial cell development
columnar/cuboidal epithelial cell differentiation
digestive tract development
digestive system development
lung development
respiratory tube development
epithelial cell development
respiratory system development
DNA-binding transcription repressor activity, RNA polymerase II-specific
sequence-specific DNA binding
positive regulation of apoptotic process
positive regulation of programmed cell death
epithelial cell differentiation
positive regulation of cell death
negative regulation of cell differentiation
tube development
negative regulation of transcription by RNA polymerase II
negative regulation of developmental process
positive regulation of cell differentiation
epithelium development
negative regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
positive regulation of developmental process