SPINT2 [The Human Chemical-Genetic Interaction Map Project]

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======= SPINT2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPINT2
  * **<color #00a2e8>Official Name</color>**: serine peptidase inhibitor, Kunitz type 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10653|10653]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43291|O43291]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SPINT2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SPINT2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605124|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Kunitz BPTI|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|epithelial cell morphogenesis involved in placental branching|
|epithelial cell differentiation involved in embryonic placenta development|
|branching involved in labyrinthine layer morphogenesis|
|labyrinthine layer morphogenesis|
|basement membrane organization|
|negative regulation of neural precursor cell proliferation|
|cell differentiation involved in embryonic placenta development|
|embryonic placenta morphogenesis|
|epithelial cell morphogenesis|
|endopeptidase inhibitor activity|
|labyrinthine layer development|
|embryonic placenta development|
|regulation of neural precursor cell proliferation|
|neural tube closure|
|tube closure|
|serine-type endopeptidase inhibitor activity|
|primary neural tube formation|
|response to BMP|
|cellular response to BMP stimulus|
|neural tube formation|
|embryonic epithelial tube formation|
|epithelial tube formation|
|morphogenesis of embryonic epithelium|
|tube formation|
|placenta development|
|morphogenesis of a branching epithelium|
|neural tube development|
|morphogenesis of a branching structure|
|negative regulation of cell-cell adhesion|
|epithelial cell development|
|establishment or maintenance of cell polarity|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|epithelial tube morphogenesis|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|extracellular matrix organization|
|negative regulation of proteolysis|
|in utero embryonic development|
|extracellular structure organization|
|regulation of cell-cell adhesion|
|regulation of endopeptidase activity|
|reproductive structure development|
|reproductive system development|
|morphogenesis of an epithelium|
|embryonic organ development|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|cellular response to growth factor stimulus|
|response to growth factor|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|developmental process involved in reproduction|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|regulation of cell adhesion|
|cell morphogenesis|
|regulation of proteolysis|
|negative regulation of catalytic activity|
|cellular component morphogenesis|
|tube development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|embryo development|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|epithelium development|
|negative regulation of molecular function|
|cellular response to endogenous stimulus|
|regulation of hydrolase activity|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|regulation of cell population proliferation|
|cell development|
|tissue development|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17404
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SPINT2 Expression in NALM6 Cells: 3.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>