SPINT2

• Official Symbol: SPINT2
• Official Name: serine peptidase inhibitor, Kunitz type 2
• Aliases and Previous Symbols: N/A
• Entrez ID: 10653
• UniProt: O43291
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
• UniProt Summary: Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 17404
• Expression level (log2 read counts): 3.81

Expression Distribution

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SPINT2 Expression in NALM6 Cells: 3.81