SPO11 [The Human Chemical-Genetic Interaction Map Project]

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======= SPO11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPO11
  * **<color #00a2e8>Official Name</color>**: SPO11 initiator of meiotic double stranded breaks
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23626|23626]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5K1|Q9Y5K1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SPO11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SPO11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605114|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2. {ECO:0000250|UniProtKB:Q9WTK8}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SPO11 like|
|TP6A N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endodeoxyribonuclease activity, producing 3-phosphomonoesters|
|double-strand break repair involved in meiotic recombination|
|meiotic DNA double-strand break processing|
|meiotic DNA double-strand break formation|
|meiotic telomere clustering|
|chromosome localization to nuclear envelope involved in homologous chromosome segregation|
|telomere localization|
|isomerase activity|
|synaptonemal complex assembly|
|DNA double-strand break processing|
|synaptonemal complex organization|
|DNA catabolic process, endonucleolytic|
|male meiosis I|
|DNA catabolic process|
|synapsis|
|male meiotic nuclear division|
|chromosome, telomeric region|
|ovarian follicle development|
|reciprocal meiotic recombination|
|homologous recombination|
|homologous chromosome segregation|
|protein localization to chromosome|
|chromosome organization involved in meiotic cell cycle|
|establishment of chromosome localization|
|chromosome localization|
|oogenesis|
|female gonad development|
|meiotic chromosome segregation|
|development of primary female sexual characteristics|
|female sex differentiation|
|meiosis I|
|meiosis I cell cycle process|
|female gamete generation|
|spermatid development|
|meiotic nuclear division|
|spermatid differentiation|
|meiotic cell cycle process|
|double-strand break repair|
|gonad development|
|development of primary sexual characteristics|
|nuclear chromosome segregation|
|DNA recombination|
|meiotic cell cycle|
|germ cell development|
|sex differentiation|
|chromosome segregation|
|nuclear division|
|nucleic acid phosphodiester bond hydrolysis|
|organelle fission|
|cellular process involved in reproduction in multicellular organism|
|establishment of organelle localization|
|nucleobase-containing compound catabolic process|
|reproductive structure development|
|reproductive system development|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|organic cyclic compound catabolic process|
|DNA repair|
|spermatogenesis|
|male gamete generation|
|organelle localization|
|developmental process involved in reproduction|
|gamete generation|
|protein localization to organelle|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|cellular macromolecule catabolic process|
|multi-organism reproductive process|
|cell cycle process|
|macromolecule catabolic process|
|chromosome organization|
|cell cycle|
|reproductive process|
|reproduction|
|DNA binding|
|ATP binding|
|cellular protein localization|
|cellular macromolecule localization|
|cell development|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14421
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SPO11 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>