SPO11

Entrez Summary: N/A
UniProt Summary: Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2. {ECO:0000250|UniProtKB:Q9WTK8}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

SPO11 like
TP6A N

endodeoxyribonuclease activity, producing 3-phosphomonoesters
double-strand break repair involved in meiotic recombination
meiotic DNA double-strand break processing
meiotic DNA double-strand break formation
meiotic telomere clustering
chromosome localization to nuclear envelope involved in homologous chromosome segregation
telomere localization
isomerase activity
synaptonemal complex assembly
DNA double-strand break processing
synaptonemal complex organization
DNA catabolic process, endonucleolytic
male meiosis I
DNA catabolic process
synapsis
male meiotic nuclear division
chromosome, telomeric region
ovarian follicle development
reciprocal meiotic recombination
homologous recombination
homologous chromosome segregation
protein localization to chromosome
chromosome organization involved in meiotic cell cycle
establishment of chromosome localization
chromosome localization
oogenesis
female gonad development
meiotic chromosome segregation
development of primary female sexual characteristics
female sex differentiation
meiosis I
meiosis I cell cycle process
female gamete generation
spermatid development
meiotic nuclear division
spermatid differentiation
meiotic cell cycle process
double-strand break repair
gonad development
development of primary sexual characteristics