SPPL2B

Entrez Summary: This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Expression Distribution

integral component of cytoplasmic side of endoplasmic reticulum membrane
aspartic endopeptidase activity, intramembrane cleaving
Golgi-associated vesicle membrane
membrane protein intracellular domain proteolysis
membrane protein ectodomain proteolysis
integral component of lumenal side of endoplasmic reticulum membrane
membrane protein proteolysis
regulation of tumor necrosis factor-mediated signaling pathway
regulation of cytokine-mediated signaling pathway
regulation of response to cytokine stimulus
endosome membrane
actin cytoskeleton
lysosomal membrane
centrosome
Golgi membrane
protein homodimerization activity
regulation of immune response
proteolysis
regulation of immune system process
membrane