SPRY2

Gene Information

Official Symbol: SPRY2
Official Name: sprouty RTK signaling antagonist 2
Aliases and Previous Symbols: N/A
Entrez ID: 10253
UniProt: O43597
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008].
UniProt Summary: May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. {ECO:0000269|PubMed:10887178}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12182
Expression level (log2 read counts): 4.45

Expression Distribution

negative regulation of neurotrophin TRK receptor signaling pathway
lung growth
bud elongation involved in lung branching
negative regulation of vascular endothelial growth factor signaling pathway
protein serine/threonine kinase inhibitor activity
negative regulation of cellular response to vascular endothelial growth factor stimulus
regulation of neurotrophin TRK receptor signaling pathway
negative regulation of fibroblast growth factor receptor signaling pathway
branch elongation of an epithelium
regulation of vascular endothelial growth factor signaling pathway
regulation of cellular response to vascular endothelial growth factor stimulus
negative regulation of peptidyl-threonine phosphorylation
epithelial tube branching involved in lung morphogenesis
axis elongation
establishment of mitotic spindle orientation
protein serine/threonine kinase activator activity
regulation of fibroblast growth factor receptor signaling pathway
establishment of mitotic spindle localization
establishment of spindle orientation
cellular response to vascular endothelial growth factor stimulus
lung morphogenesis
establishment of spindle localization
regulation of peptidyl-threonine phosphorylation
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of GTPase activity
spindle localization
negative regulation of ERBB signaling pathway
negative regulation of Ras protein signal transduction
negative regulation of small GTPase mediated signal transduction
negative regulation of ERK1 and ERK2 cascade
negative regulation of MAP kinase activity
regulation of epidermal growth factor receptor signaling pathway
regulation of ERBB signaling pathway
ruffle membrane
organ growth
cellular response to leukemia inhibitory factor
response to leukemia inhibitory factor
inner ear morphogenesis
negative regulation of angiogenesis
microtubule cytoskeleton organization involved in mitosis