SQLE

Entrez Summary: N/A
UniProt Summary: Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 8/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	0/21
liver	0/20
lung	2/75
lymphocyte	0/16
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

Screen	Score
Fluvastatin 2.2μM R06 exp282	-3.16
THZ531 0.225μM R08 exp444	-1.99

FAD binding 3
SE

squalene monooxygenase activity
lipid droplet formation
lipid droplet organization
lipid storage
FAD binding
cholesterol biosynthetic process
regulation of sterol biosynthetic process
secondary alcohol biosynthetic process
regulation of cholesterol biosynthetic process
sterol biosynthetic process
regulation of cholesterol metabolic process
regulation of alcohol biosynthetic process
regulation of steroid biosynthetic process
alcohol biosynthetic process
regulation of steroid metabolic process
cholesterol metabolic process
steroid biosynthetic process
secondary alcohol metabolic process
sterol metabolic process
maintenance of location
organic hydroxy compound biosynthetic process
regulation of lipid biosynthetic process
steroid metabolic process
alcohol metabolic process
lipid localization
regulation of lipid metabolic process
regulation of small molecule metabolic process
organic hydroxy compound metabolic process
lipid biosynthetic process
small molecule biosynthetic process
intracellular membrane-bounded organelle
organelle assembly
endoplasmic reticulum membrane
oxidation-reduction process
endoplasmic reticulum
lipid metabolic process
organic cyclic compound biosynthetic process
regulation of cell population proliferation
small molecule metabolic process