SQRDL

Entrez Summary: N/A
UniProt Summary: Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro). {ECO:0000269|PubMed:22852582}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Mubritinib 0.2μM R01 exp48	-1.82
Ribavirin 10 to 15μM on day4 R04 exp160	1.7

sulfide:quinone oxidoreductase activity
sulfide oxidation, using sulfide:quinone oxidoreductase
hydrogen sulfide metabolic process
sulfide oxidation
quinone binding
toxin metabolic process
FAD binding
secondary metabolic process
sulfur compound metabolic process
mitochondrial inner membrane
drug metabolic process
oxidation-reduction process