SRMS

Official Symbol: SRMS
Official Name: src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
Aliases and Previous Symbols: N/A
Entrez ID: 6725
UniProt: Q9H3Y6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. May be involved in proliferation or differentiation of keratinocytes in the skin. {ECO:0000269|PubMed:23822091}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

peptidyl-tyrosine autophosphorylation
non-membrane spanning protein tyrosine kinase activity
extrinsic component of cytoplasmic side of plasma membrane
protein tyrosine kinase activity
peptidyl-tyrosine phosphorylation
peptidyl-tyrosine modification
protein autophosphorylation
signaling receptor binding
transmembrane receptor protein tyrosine kinase signaling pathway
enzyme linked receptor protein signaling pathway
peptidyl-amino acid modification
protein phosphorylation
negative regulation of signal transduction
phosphorylation
negative regulation of cell communication
negative regulation of signaling
ATP binding
negative regulation of response to stimulus