SRP54 [The Human Chemical-Genetic Interaction Map Project]

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======= SRP54 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SRP54
  * **<color #00a2e8>Official Name</color>**: signal recognition particle 54
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6729|6729]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61011|P61011]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SRP54&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SRP54|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604857|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein).

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|cobW|
|SRP54 N|
|SRP SPB|
|SRP54|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|
|endoplasmic reticulum signal peptide binding|
|signal recognition particle, endoplasmic reticulum targeting|
|7S RNA binding|
|SRP-dependent cotranslational protein targeting to membrane, translocation|
|ribonucleoprotein complex binding|
|intracellular protein transmembrane transport|
|drug binding|
|protein transmembrane transport|
|GDP binding|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|protein localization to endoplasmic reticulum|
|protein targeting to membrane|
|establishment of protein localization to membrane|
|GTPase activity|
|protein targeting|
|GTP binding|
|nuclear speck|
|establishment of protein localization to organelle|
|protein localization to membrane|
|protein localization to organelle|
|cellular protein-containing complex assembly|
|nucleolus|
|intracellular protein transport|
|response to drug|
|transmembrane transport|
|RNA binding|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.79|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-1.72|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|1.74|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|1.92|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|2.06|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.2|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.43|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|3.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 711/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|26/28|
|blood|27/28|
|bone|25/26|
|breast|32/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|72/75|
|lymphocyte|14/16|
|ovary|23/26|
|pancreas|23/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 137
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SRP54 Expression in NALM6 Cells: 6.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>