SRP54

Entrez Summary: N/A
UniProt Summary: Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein).

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Thapsigargin 0.005μM R07 exp407	-1.79
Salubrinal 20μM R07 exp399	-1.72
CCT251545 0.2μM R06 exp271	1.74
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	1.92
HMS-I2 5μM R06 exp287	2.06
TRAIL 50ng/ml R00 exp36	2.2
TRAIL 5ng/ml R00 exp35	2.43
Actinomycin-D 0.01μM R00 exp4	3.89

Global Fraction of Cell Lines Where Essential: 711/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	26/28
blood	27/28
bone	25/26
breast	32/33
central nervous system	55/56
cervix	4/4
colorectal	16/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	72/75
lymphocyte	14/16
ovary	23/26
pancreas	23/24
peripheral nervous system	15/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	29/29
uterus	5/5

Expression Distribution

SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition
endoplasmic reticulum signal peptide binding
signal recognition particle, endoplasmic reticulum targeting
7S RNA binding
SRP-dependent cotranslational protein targeting to membrane, translocation
ribonucleoprotein complex binding
intracellular protein transmembrane transport
drug binding
protein transmembrane transport
GDP binding
SRP-dependent cotranslational protein targeting to membrane
cotranslational protein targeting to membrane
protein targeting to ER
establishment of protein localization to endoplasmic reticulum
protein localization to endoplasmic reticulum
protein targeting to membrane
establishment of protein localization to membrane
GTPase activity
protein targeting
GTP binding
nuclear speck
establishment of protein localization to organelle
protein localization to membrane
protein localization to organelle
cellular protein-containing complex assembly
nucleolus
intracellular protein transport
response to drug
transmembrane transport
RNA binding
protein transport
intracellular transport
peptide transport
protein-containing complex assembly
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport