SSC5D

Official Symbol: SSC5D
Official Name: scavenger receptor cysteine rich family member with 5 domains
Aliases and Previous Symbols: N/A
Entrez ID: 284297
UniProt: A1L4H1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

detection of bacterial lipoprotein
negative regulation of interleukin-8 secretion
response to bacterial lipoprotein
detection of molecule of bacterial origin
detection of bacterium
detection of other organism
negative regulation of interleukin-8 production
detection of external biotic stimulus
detection of biotic stimulus
regulation of interleukin-8 secretion
laminin binding
fibronectin binding
extracellular matrix binding
scavenger receptor activity
negative regulation of cytokine secretion
regulation of interleukin-8 production
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
negative regulation of protein secretion
negative regulation of peptide secretion
negative regulation of protein transport
negative regulation of establishment of protein localization
negative regulation of secretion by cell
regulation of cytokine secretion
negative regulation of secretion
negative regulation of cytokine production
response to molecule of bacterial origin
defense response to bacterium
collagen-containing extracellular matrix
external side of plasma membrane
regulation of protein secretion
negative regulation of transport
regulation of peptide secretion
detection of chemical stimulus
endocytosis
import into cell
response to bacterium
detection of stimulus
regulation of cytokine production
regulation of protein transport