ST18

Gene Information

Official Symbol: ST18
Official Name: ST18 C2H2C-type zinc finger transcription factor
Aliases and Previous Symbols: N/A
Entrez ID: 9705
UniProt: O60284
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5'-AAAGTTT-3' separated by 2-9 nucleotides. Represses basal transcription activity from target promoters (By similarity). Inhibits colony formation in cultured breast cancer cells. {ECO:0000250, ECO:0000269|PubMed:15489893}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13831
Expression level (log2 read counts): -0.13

Expression Distribution

Screen	Score
MK-1775 0.32μM R02 exp75	-1.76
Brefeldin A 0.02μM R00 exp8	-1.7

zf-C2HC
MYT1

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
interleukin-6-mediated signaling pathway
regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
cellular response to interleukin-6
response to interleukin-6
protein-DNA complex
interleukin-1-mediated signaling pathway
tumor necrosis factor-mediated signaling pathway
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of cysteine-type endopeptidase activity
positive regulation of endopeptidase activity
cellular response to interleukin-1
positive regulation of apoptotic signaling pathway
positive regulation of peptidase activity
response to interleukin-1
regulation of cysteine-type endopeptidase activity involved in apoptotic process
cellular response to tumor necrosis factor
regulation of cysteine-type endopeptidase activity
response to tumor necrosis factor
RNA polymerase II regulatory region sequence-specific DNA binding
positive regulation of proteolysis
regulation of apoptotic signaling pathway
regulation of endopeptidase activity
regulation of peptidase activity
DNA-binding transcription activator activity, RNA polymerase II-specific
RNA polymerase II proximal promoter sequence-specific DNA binding
positive regulation of apoptotic process
positive regulation of programmed cell death
cytokine-mediated signaling pathway
negative regulation of cell population proliferation
positive regulation of cell death
regulation of proteolysis
positive regulation of hydrolase activity
zinc ion binding
cellular response to cytokine stimulus
response to cytokine
positive regulation of transcription by RNA polymerase II
regulation of hydrolase activity
positive regulation of catalytic activity
regulation of apoptotic process