STAM

Entrez Summary: N/A
UniProt Summary: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ESCRT-0 complex
regulation of extracellular exosome assembly
positive regulation of exosomal secretion
regulation of exosomal secretion
ubiquitin-like protein ligase binding
multivesicular body assembly
multivesicular body organization
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of ERBB signaling pathway
SH3/SH2 adaptor activity
endosome organization
regulation of epidermal growth factor receptor signaling pathway
positive regulation of exocytosis
regulation of ERBB signaling pathway
early endosome membrane
macroautophagy
regulation of organelle assembly
regulation of exocytosis
endosomal transport
process utilizing autophagic mechanism
autophagy
protein deubiquitination
protein modification by small protein removal
vesicle organization
positive regulation of secretion by cell
endomembrane system organization
positive regulation of secretion
positive regulation of cellular component biogenesis
regulation of vesicle-mediated transport
regulation of secretion by cell
organelle assembly
regulation of secretion
membrane organization
regulation of cellular component biogenesis
protein modification by small protein conjugation or removal
positive regulation of transport
intracellular protein transport
negative regulation of signal transduction
proteolysis
regulation of organelle organization