STAR

Entrez Summary: The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jul 2008].
UniProt Summary: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

phthalate metabolic process
circadian sleep/wake cycle, REM sleep
insecticide metabolic process
positive regulation of bile acid metabolic process
biphenyl metabolic process
positive regulation of bile acid biosynthetic process
circadian sleep/wake cycle, sleep
cellular response to luteinizing hormone stimulus
dibenzo-p-dioxin metabolic process
circadian sleep/wake cycle process
response to luteinizing hormone
testosterone biosynthetic process
mitochondrial crista
circadian sleep/wake cycle
regulation of bile acid biosynthetic process
response to fungicide
cellular response to follicle-stimulating hormone stimulus
cellular response to interferon-alpha
regulation of bile acid metabolic process
response to herbicide
estrogen biosynthetic process
cellular response to epinephrine stimulus
sleep
C21-steroid hormone biosynthetic process
response to follicle-stimulating hormone
glucocorticoid metabolic process
intracellular cholesterol transport
response to epinephrine
response to insecticide
intracellular sterol transport
positive regulation of steroid biosynthetic process
cellular response to gonadotropin stimulus
response to corticosterone
response to interferon-alpha
cellular response to growth hormone stimulus
response to leptin
toxin metabolic process
circadian behavior
rhythmic behavior
response to lead ion