STOM
Gene Information
- Official Symbol: STOM
- Official Name: stomatin
- Aliases and Previous Symbols: N/A
- Entrez ID: 2040
- UniProt: P27105
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity.
Pfam Domains GO Terms
Pfam Domains
| Band 7 |
GO Terms
| regulation of acid-sensing ion channel activity |
| positive regulation by host of viral genome replication |
| modulation by host of viral genome replication |
| positive regulation by host of viral process |
| RNA polymerase binding |
| modulation by host of viral process |
| positive regulation of protein targeting to membrane |
| positive regulation of viral genome replication |
| regulation of protein targeting to membrane |
| regulation of sodium ion transmembrane transporter activity |
| azurophil granule membrane |
| positive regulation of viral life cycle |
| regulation of sodium ion transmembrane transport |
| modification by host of symbiont morphology or physiology |
| tertiary granule membrane |
| interaction with symbiont |
| regulation of protein targeting |
| regulation of sodium ion transport |
| specific granule membrane |
| regulation of viral genome replication |
| melanosome |
| positive regulation of viral process |
| modification of morphology or physiology of other organism involved in symbiotic interaction |
| positive regulation of protein localization to membrane |
| blood microparticle |
| vesicle |
| regulation of viral life cycle |
| positive regulation of intracellular protein transport |
| modification of morphology or physiology of other organism |
| regulation of cation channel activity |
| regulation of protein localization to membrane |
| regulation of viral process |
| positive regulation of intracellular transport |
| regulation of symbiosis, encompassing mutualism through parasitism |
| membrane raft |
| regulation of intracellular protein transport |
| regulation of ion transmembrane transporter activity |
| regulation of transmembrane transporter activity |
| regulation of transporter activity |
| positive regulation of cellular protein localization |
| regulation of cation transmembrane transport |
| protein homooligomerization |
| regulation of intracellular transport |
| cytoskeleton |
| regulation of metal ion transport |
| positive regulation of protein transport |
| positive regulation of establishment of protein localization |
| regulation of ion transmembrane transport |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| positive regulation of multi-organism process |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| protein complex oligomerization |
| myeloid cell activation involved in immune response |
| regulation of cellular protein localization |
| regulation of transmembrane transport |
| myeloid leukocyte activation |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| perinuclear region of cytoplasm |
| regulation of ion transport |
| regulated exocytosis |
| regulation of protein transport |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| leukocyte mediated immunity |
| regulation of multi-organism process |
| symbiotic process |
| exocytosis |
| interspecies interaction between organisms |
| protein homodimerization activity |
| regulation of cellular localization |
| leukocyte activation |
| positive regulation of transport |
| secretion by cell |
| endoplasmic reticulum |
| regulation of protein localization |
| export from cell |
| cell activation |
| immune effector process |
| secretion |
| mitochondrion |
| integral component of plasma membrane |
| protein-containing complex assembly |
| extracellular space |
| protein-containing complex subunit organization |
| regulation of transport |
| immune response |
| vesicle-mediated transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18516
- Expression level (log2 read counts): 3.64
Expression Distribution
STOM Expression in NALM6 Cells: 3.64
