STX17 [The Human Chemical-Genetic Interaction Map Project]

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======= STX17 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STX17
  * **<color #00a2e8>Official Name</color>**: syntaxin 17
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55014|55014]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P56962|P56962]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STX17&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STX17|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604204|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  SNAREs, soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane (PubMed:23217709, PubMed:25686604). May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355). {ECO:0000269|PubMed:21545355, ECO:0000269|PubMed:23217709, ECO:0000269|PubMed:25686604}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SNARE|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endoplasmic reticulum-Golgi intermediate compartment organization|
|autophagosome membrane docking|
|smooth endoplasmic reticulum membrane|
|protein localization to phagophore assembly site|
|mitochondria-associated endoplasmic reticulum membrane|
|HOPS complex|
|SNAP receptor activity|
|autophagosome maturation|
|autophagosome membrane|
|COPII-coated ER to Golgi transport vesicle|
|SNARE complex|
|ER to Golgi transport vesicle membrane|
|rough endoplasmic reticulum|
|autophagosome assembly|
|vesicle docking|
|autophagosome organization|
|SNARE binding|
|autophagosome|
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|vesicle fusion|
|endomembrane system|
|endoplasmic reticulum-Golgi intermediate compartment|
|organelle membrane fusion|
|protein phosphatase binding|
|organelle fusion|
|vacuole organization|
|membrane fusion|
|Golgi organization|
|macroautophagy|
|organelle localization by membrane tethering|
|membrane docking|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|protein-containing complex disassembly|
|process utilizing autophagic mechanism|
|autophagy|
|vesicle organization|
|lysosomal membrane|
|Golgi vesicle transport|
|cellular component disassembly|
|endomembrane system organization|
|protein kinase binding|
|organelle localization|
|organelle assembly|
|membrane organization|
|endoplasmic reticulum membrane|
|intracellular protein transport|
|mitochondrion|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp155|UNC1999 2μM R03 exp155]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17982
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STX17 Expression in NALM6 Cells: 4.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>