STX17

Entrez Summary: N/A
UniProt Summary: SNAREs, soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane (PubMed:23217709, PubMed:25686604). May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355). {ECO:0000269|PubMed:21545355, ECO:0000269|PubMed:23217709, ECO:0000269|PubMed:25686604}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

endoplasmic reticulum-Golgi intermediate compartment organization
autophagosome membrane docking
smooth endoplasmic reticulum membrane
protein localization to phagophore assembly site
mitochondria-associated endoplasmic reticulum membrane
HOPS complex
SNAP receptor activity
autophagosome maturation
autophagosome membrane
COPII-coated ER to Golgi transport vesicle
SNARE complex
ER to Golgi transport vesicle membrane
rough endoplasmic reticulum
autophagosome assembly
vesicle docking
autophagosome organization
SNARE binding
autophagosome
endoplasmic reticulum-Golgi intermediate compartment membrane
vesicle fusion
endomembrane system
endoplasmic reticulum-Golgi intermediate compartment
organelle membrane fusion
protein phosphatase binding
organelle fusion
vacuole organization
membrane fusion
Golgi organization
macroautophagy
organelle localization by membrane tethering
membrane docking
endoplasmic reticulum to Golgi vesicle-mediated transport
protein-containing complex disassembly
process utilizing autophagic mechanism
autophagy
vesicle organization
lysosomal membrane
Golgi vesicle transport
cellular component disassembly
endomembrane system organization