STX18

Entrez Summary: N/A
UniProt Summary: Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. {ECO:0000269|PubMed:15029241}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 145/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	5/28
blood	1/28
bone	1/26
breast	17/33
central nervous system	14/56
cervix	1/4
colorectal	2/17
esophagus	0/13
fibroblast	0/1
gastric	2/16
kidney	10/21
liver	0/20
lung	10/75
lymphocyte	3/16
ovary	5/26
pancreas	3/24
peripheral nervous system	5/16
plasma cell	3/15
prostate	1/1
skin	5/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	8/29
uterus	2/5

Expression Distribution

positive regulation of ER to Golgi vesicle-mediated transport
endoplasmic reticulum membrane organization
regulation of ER to Golgi vesicle-mediated transport
regulation of Golgi organization
SNAP receptor activity
SNARE complex
endoplasmic reticulum organization
positive regulation of organelle assembly
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
membrane fusion
positive regulation of intracellular transport
regulation of organelle assembly
protein domain specific binding
regulation of intracellular transport
Golgi vesicle transport
endomembrane system organization
positive regulation of cellular component biogenesis
regulation of vesicle-mediated transport
Golgi membrane
positive regulation of organelle organization
membrane organization
regulation of cellular localization
endoplasmic reticulum membrane
regulation of cellular component biogenesis
positive regulation of transport
intracellular protein transport
endoplasmic reticulum
positive regulation of cellular component organization
regulation of organelle organization
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport
regulation of transport
vesicle-mediated transport