STX7

Entrez Summary: The protein encoded by this gene is a syntaxin family membrane receptor involved in vesicle transport. The encoded protein binds alpha-SNAP, an important regulator of transport vesicle fusion. Along with syntaxin 13, this protein plays a role in the ordered fusion of endosomes and lysosomes with the phagosome. [provided by RefSeq, May 2016].
UniProt Summary: May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Syntaxin
SNARE

positive regulation of receptor localization to synapse
tertiary granule
positive regulation of protein localization to synapse
chloride channel inhibitor activity
azurophil granule
regulation of receptor localization to synapse
positive regulation of T cell mediated cytotoxicity
regulation of protein localization to synapse
SNAP receptor activity
regulation of T cell mediated cytotoxicity
immunological synapse
SNARE complex
positive regulation of T cell mediated immunity
syntaxin binding
positive regulation of leukocyte mediated cytotoxicity
endocytic vesicle
vesicle docking
SNARE binding
positive regulation of cell killing
regulation of T cell mediated immunity
vesicle fusion
endomembrane system
organelle membrane fusion
regulation of leukocyte mediated cytotoxicity
regulation of protein localization to plasma membrane
organelle fusion
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
regulation of cell killing
positive regulation of adaptive immune response
positive regulation of lymphocyte mediated immunity
regulation of protein localization to cell periphery
recycling endosome
synaptic vesicle
late endosome
membrane fusion
positive regulation of leukocyte mediated immunity
vesicle
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
regulation of lymphocyte mediated immunity
early endosome membrane