STYXL1 [The Human Chemical-Genetic Interaction Map Project]

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======= STYXL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STYXL1
  * **<color #00a2e8>Official Name</color>**: serine/threonine/tyrosine interacting like 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51657|51657]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6J8|Q9Y6J8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STYXL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STYXL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616695|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probable pseudophosphatase. Contains a Ser residue instead of a conserved Cys residue in the dsPTPase catalytic loop which probably renders it catalytically inactive as a phosphatase. The binding pocket may be however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rhodanese|
|DSPc|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of stress granule assembly|
|pseudophosphatase activity|
|regulation of stress granule assembly|
|protein phosphatase inhibitor activity|
|negative regulation of organelle assembly|
|protein tyrosine/serine/threonine phosphatase activity|
|positive regulation of intrinsic apoptotic signaling pathway|
|negative regulation of phosphoprotein phosphatase activity|
|negative regulation of protein dephosphorylation|
|protein phosphatase binding|
|negative regulation of phosphatase activity|
|negative regulation of dephosphorylation|
|regulation of phosphoprotein phosphatase activity|
|negative regulation of protein complex assembly|
|regulation of protein dephosphorylation|
|regulation of intrinsic apoptotic signaling pathway|
|positive regulation of apoptotic signaling pathway|
|regulation of phosphatase activity|
|regulation of dephosphorylation|
|protein dephosphorylation|
|regulation of organelle assembly|
|positive regulation of neuron projection development|
|dephosphorylation|
|positive regulation of neuron differentiation|
|mitochondrial matrix|
|negative regulation of organelle organization|
|positive regulation of cell projection organization|
|regulation of apoptotic signaling pathway|
|regulation of protein complex assembly|
|negative regulation of hydrolase activity|
|positive regulation of neurogenesis|
|regulation of neuron projection development|
|positive regulation of nervous system development|
|positive regulation of cell development|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of catalytic activity|
|regulation of neurogenesis|
|regulation of nervous system development|
|regulation of cell development|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|positive regulation of cellular component organization|
|mitochondrion|
|regulation of hydrolase activity|
|regulation of organelle organization|
|positive regulation of developmental process|
|generation of neurons|
|regulation of apoptotic process|
|regulation of programmed cell death|
|neurogenesis|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12548
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STYXL1 Expression in NALM6 Cells: 3.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>