STYXL1

Gene Information

Official Symbol: STYXL1
Official Name: serine/threonine/tyrosine interacting like 1
Aliases and Previous Symbols: N/A
Entrez ID: 51657
UniProt: Q9Y6J8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Probable pseudophosphatase. Contains a Ser residue instead of a conserved Cys residue in the dsPTPase catalytic loop which probably renders it catalytically inactive as a phosphatase. The binding pocket may be however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12548
Expression level (log2 read counts): 3.84

Expression Distribution

Rhodanese
DSPc

negative regulation of stress granule assembly
pseudophosphatase activity
regulation of stress granule assembly
protein phosphatase inhibitor activity
negative regulation of organelle assembly
protein tyrosine/serine/threonine phosphatase activity
positive regulation of intrinsic apoptotic signaling pathway
negative regulation of phosphoprotein phosphatase activity
negative regulation of protein dephosphorylation
protein phosphatase binding
negative regulation of phosphatase activity
negative regulation of dephosphorylation
regulation of phosphoprotein phosphatase activity
negative regulation of protein complex assembly
regulation of protein dephosphorylation
regulation of intrinsic apoptotic signaling pathway
positive regulation of apoptotic signaling pathway
regulation of phosphatase activity
regulation of dephosphorylation
protein dephosphorylation
regulation of organelle assembly
positive regulation of neuron projection development
dephosphorylation
positive regulation of neuron differentiation
mitochondrial matrix
negative regulation of organelle organization
positive regulation of cell projection organization
regulation of apoptotic signaling pathway
regulation of protein complex assembly
negative regulation of hydrolase activity
positive regulation of neurogenesis
regulation of neuron projection development
positive regulation of nervous system development
positive regulation of cell development
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
positive regulation of apoptotic process
positive regulation of programmed cell death
regulation of neuron differentiation