SUCNR1

Gene Information

Official Symbol: SUCNR1
Official Name: succinate receptor 1
Aliases and Previous Symbols: N/A
Entrez ID: 56670
UniProt: Q9BXA5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Receptor for succinate. {ECO:0000269|PubMed:15141213}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18150
Expression level (log2 read counts): -3.28

Expression Distribution

Screen	Score
NN-Diethyl-meta-toluamide 500μM R08 exp438	1.74
Ibrutinib 10μM R08 exp442	2.14

regulation of angiotensin metabolic process
renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure
renin secretion into blood stream
macrophage activation involved in immune response
interleukin-1 beta production
regulation of systemic arterial blood pressure by circulatory renin-angiotensin
interleukin-1 production
regulation of systemic arterial blood pressure by renin-angiotensin
renal system process involved in regulation of systemic arterial blood pressure
regulation of systemic arterial blood pressure by hormone
regulation of systemic arterial blood pressure mediated by a chemical signal
endocrine process
macrophage activation
regulation of systemic arterial blood pressure
renal system process
positive regulation of chemotaxis
positive regulation of inflammatory response
cytokine production
response to calcium ion
protein secretion
establishment of protein localization to extracellular region
protein localization to extracellular region
peptide secretion
regulation of blood pressure
glucose homeostasis
carbohydrate homeostasis
regulation of chemotaxis
regulation of inflammatory response
response to metal ion
blood circulation
circulatory system process
positive regulation of defense response
myeloid cell activation involved in immune response
response to inorganic substance
positive regulation of locomotion
myeloid leukocyte activation
positive regulation of response to external stimulus
leukocyte activation involved in immune response
cell activation involved in immune response
G protein-coupled receptor activity