SYCP3

Entrez Summary: This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2010].
UniProt Summary: Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells (By similarity). Required for normal meiosis during spermatogenesis and male fertility (PubMed:14643120). Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2 (By similarity). {ECO:0000250|UniProtKB:P70281, ECO:0000269|PubMed:14643120}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

spermatogenesis, exchange of chromosomal proteins
sperm chromatin condensation
lateral element
spermatid nucleus differentiation
male meiosis I
synaptonemal complex
histone exchange
male meiotic nuclear division
chromosome, centromeric region
ATP-dependent chromatin remodeling
meiosis I
meiosis I cell cycle process
nucleus organization
spermatid development
meiotic nuclear division
spermatid differentiation
nucleosome organization
chromatin remodeling
meiotic cell cycle process
DNA packaging
meiotic cell cycle
protein-DNA complex subunit organization
germ cell development
nuclear division
DNA conformation change
organelle fission
cellular process involved in reproduction in multicellular organism
cell division
spermatogenesis
male gamete generation
developmental process involved in reproduction
gamete generation
chromatin organization
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
multi-organism reproductive process
cell cycle process
chromosome organization
cell cycle