SYNPO

Entrez Summary: N/A
UniProt Summary: Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

spine apparatus assembly
positive regulation of postsynaptic cytosolic calcium concentration
modification of dendritic spine
spine apparatus
modification of postsynaptic structure
regulation of postsynaptic cytosolic calcium ion concentration
modification of synaptic structure
postsynaptic modulation of chemical synaptic transmission
regulation of long-term neuronal synaptic plasticity
visual learning
visual behavior
regulation of neuronal synaptic plasticity
positive regulation of actin filament bundle assembly
stress fiber
associative learning
Schaffer collateral - CA1 synapse
regulation of actin filament bundle assembly
bicellular tight junction
Z disc
perikaryon
learning
dendritic spine
regulation of synaptic plasticity
positive regulation of supramolecular fiber organization
postsynaptic membrane
actin cytoskeleton
positive regulation of cytoskeleton organization
postsynaptic density
learning or memory
regulation of actin filament organization
actin binding
synapse organization
positive regulation of cytosolic calcium ion concentration
cognition
response to light stimulus
regulation of cytosolic calcium ion concentration
regulation of actin cytoskeleton organization
glutamatergic synapse
regulation of supramolecular fiber organization
regulation of actin filament-based process