SYT3

Entrez Summary: N/A
UniProt Summary: Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain. Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:P40748, ECO:0000269|PubMed:23999003}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of dendrite extension
regulation of dendrite extension
exocytic vesicle
clathrin binding
regulation of dopamine secretion
calcium-ion regulated exocytosis
transport vesicle membrane
regulation of calcium ion-dependent exocytosis
syntaxin binding
calcium-dependent phospholipid binding
phosphatidylserine binding
regulation of catecholamine secretion
SNARE binding
cellular response to calcium ion
regulation of amine transport
regulation of response to drug
response to calcium ion
regulation of regulated secretory pathway
positive regulation of cell growth
positive regulation of developmental growth
cellular response to metal ion
cellular response to inorganic substance
regulation of exocytosis
positive regulation of growth
endosome
positive regulation of neuron projection development
regulation of developmental growth
positive regulation of neuron differentiation
response to metal ion
positive regulation of cell projection organization
regulation of cell growth
positive regulation of neurogenesis
regulation of cell morphogenesis
regulation of neuron projection development
response to inorganic substance
positive regulation of nervous system development
positive regulation of cell development
regulation of vesicle-mediated transport
regulation of neuron differentiation
regulation of growth