SYT4 [The Human Chemical-Genetic Interaction Map Project]

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======= SYT4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SYT4
  * **<color #00a2e8>Official Name</color>**: synaptotagmin 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6860|6860]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H2B2|Q9H2B2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SYT4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SYT4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600103|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:P50232, ECO:0000269|PubMed:23999003}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of short-term neuronal synaptic plasticity|
|negative regulation of dense core granule exocytosis|
|positive regulation of dense core granule exocytosis|
|vesicle fusion with vesicle|
|regulation of retrograde trans-synaptic signaling by neuropeptide|
|regulation of presynaptic dense core granule exocytosis|
|negative regulation of retrograde trans-synaptic signaling by neuropeptide|
|integral component of neuronal dense core vesicle membrane|
|dense core granule membrane|
|trans-synaptic signaling by BDNF|
|syntaxin-3 binding|
|trans-synaptic signaling by BDNF, modulating synaptic transmission|
|microvesicle|
|secretory granule maturation|
|regulation of calcium ion-dependent exocytosis of neurotransmitter|
|negative regulation of synaptic vesicle exocytosis|
|negative regulation of vesicle fusion|
|astrocyte projection|
|negative regulation of calcium ion-dependent exocytosis|
|positive regulation of glutamate secretion|
|trans-synaptic signaling, modulating synaptic transmission|
|negative regulation of neurotransmitter secretion|
|regulation of short-term neuronal synaptic plasticity|
|negative regulation of catecholamine secretion|
|regulation of glutamate secretion|
|positive regulation of amino acid transport|
|positive regulation of calcium ion-dependent exocytosis|
|calcium ion-regulated exocytosis of neurotransmitter|
|neuron projection terminus|
|positive regulation of dendrite extension|
|negative regulation of neurotransmitter transport|
|regulation of dendrite extension|
|negative regulation of amine transport|
|negative regulation of regulated secretory pathway|
|exocytic vesicle|
|syntaxin-1 binding|
|regulation of amino acid transport|
|regulation of vesicle fusion|
|positive regulation of organic acid transport|
|negative regulation of exocytosis|
|integral component of synaptic vesicle membrane|
|positive regulation of amine transport|
|secretory granule organization|
|clathrin binding|
|regulation of dopamine secretion|
|calcium-ion regulated exocytosis|
|regulation of calcium ion-dependent exocytosis|
|positive regulation of anion transport|
|regulation of neuronal synaptic plasticity|
|positive regulation of regulated secretory pathway|
|calcium-dependent phospholipid binding|
|regulation of organic acid transport|
|phosphatidylserine binding|
|negative regulation of synaptic transmission|
|regulation of catecholamine secretion|
|integral component of Golgi membrane|
|synaptic vesicle exocytosis|
|SNARE binding|
|vesicle fusion|
|organelle membrane fusion|
|regulation of synaptic vesicle exocytosis|
|cellular response to calcium ion|
|positive regulation of exocytosis|
|regulation of amine transport|
|regulation of anion transport|
|organelle fusion|
|regulation of response to drug|
|neurotransmitter secretion|
|signal release from synapse|
|regulation of neurotransmitter secretion|
|regulation of synaptic vesicle cycle|
|memory|
|synaptic vesicle cycle|
|vesicle-mediated transport in synapse|
|membrane fusion|
|negative regulation of protein secretion|
|negative regulation of peptide secretion|
|regulation of neurotransmitter transport|
|response to calcium ion|
|positive regulation of cell growth|
|regulation of regulated secretory pathway|
|signal release|
|positive regulation of developmental growth|
|neurotransmitter transport|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|regulation of synaptic plasticity|
|cellular response to metal ion|
|negative regulation of secretion by cell|
|regulation of endocytosis|
|cellular response to inorganic substance|
|regulation of exocytosis|
|negative regulation of secretion|
|developmental maturation|
|learning or memory|
|positive regulation of growth|
|positive regulation of ion transport|
|positive regulation of neuron projection development|
|negative regulation of neurogenesis|
|axon|
|cognition|
|vesicle organization|
|negative regulation of nervous system development|
|neuron projection|
|regulation of developmental growth|
|negative regulation of cell development|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|positive regulation of neuron differentiation|
|response to metal ion|
|neuronal cell body|
|negative regulation of organelle organization|
|positive regulation of cell projection organization|
|positive regulation of secretion by cell|
|regulation of cell growth|
|endomembrane system organization|
|anterograde trans-synaptic signaling|
|dendrite|
|chemical synaptic transmission|
|positive regulation of secretion|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|regulation of protein secretion|
|positive regulation of neurogenesis|
|negative regulation of transport|
|protein heterodimerization activity|
|regulation of cell morphogenesis|
|regulation of peptide secretion|
|regulation of neuron projection development|
|response to inorganic substance|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cell junction|
|regulation of vesicle-mediated transport|
|behavior|
|regulation of neuron differentiation|
|regulation of growth|
|intracellular membrane-bounded organelle|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|regulated exocytosis|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|calcium ion binding|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|head development|
|exocytosis|
|regulation of secretion|
|regulation of neurogenesis|
|membrane organization|
|protein homodimerization activity|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|central nervous system development|
|positive regulation of transport|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|regulation of anatomical structure morphogenesis|
|cell-cell signaling|
|secretion|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|nervous system process|
|generation of neurons|
|neurogenesis|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|establishment of localization in cell|
|regulation of transport|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-1.95|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-1.9|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-1.86|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.5|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15528
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SYT4 Expression in NALM6 Cells: -4.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>