SYT4
Gene Information
- Official Symbol: SYT4
- Official Name: synaptotagmin 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 6860
- UniProt: Q9H2B2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:P50232, ECO:0000269|PubMed:23999003}.
Pfam Domains GO Terms
Pfam Domains
| C2 |
GO Terms
| negative regulation of short-term neuronal synaptic plasticity |
| negative regulation of dense core granule exocytosis |
| positive regulation of dense core granule exocytosis |
| vesicle fusion with vesicle |
| regulation of retrograde trans-synaptic signaling by neuropeptide |
| regulation of presynaptic dense core granule exocytosis |
| negative regulation of retrograde trans-synaptic signaling by neuropeptide |
| integral component of neuronal dense core vesicle membrane |
| dense core granule membrane |
| trans-synaptic signaling by BDNF |
| syntaxin-3 binding |
| trans-synaptic signaling by BDNF, modulating synaptic transmission |
| microvesicle |
| secretory granule maturation |
| regulation of calcium ion-dependent exocytosis of neurotransmitter |
| negative regulation of synaptic vesicle exocytosis |
| negative regulation of vesicle fusion |
| astrocyte projection |
| negative regulation of calcium ion-dependent exocytosis |
| positive regulation of glutamate secretion |
| trans-synaptic signaling, modulating synaptic transmission |
| negative regulation of neurotransmitter secretion |
| regulation of short-term neuronal synaptic plasticity |
| negative regulation of catecholamine secretion |
| regulation of glutamate secretion |
| positive regulation of amino acid transport |
| positive regulation of calcium ion-dependent exocytosis |
| calcium ion-regulated exocytosis of neurotransmitter |
| neuron projection terminus |
| positive regulation of dendrite extension |
| negative regulation of neurotransmitter transport |
| regulation of dendrite extension |
| negative regulation of amine transport |
| negative regulation of regulated secretory pathway |
| exocytic vesicle |
| syntaxin-1 binding |
| regulation of amino acid transport |
| regulation of vesicle fusion |
| positive regulation of organic acid transport |
| negative regulation of exocytosis |
| integral component of synaptic vesicle membrane |
| positive regulation of amine transport |
| secretory granule organization |
| clathrin binding |
| regulation of dopamine secretion |
| calcium-ion regulated exocytosis |
| regulation of calcium ion-dependent exocytosis |
| positive regulation of anion transport |
| regulation of neuronal synaptic plasticity |
| positive regulation of regulated secretory pathway |
| calcium-dependent phospholipid binding |
| regulation of organic acid transport |
| phosphatidylserine binding |
| negative regulation of synaptic transmission |
| regulation of catecholamine secretion |
| integral component of Golgi membrane |
| synaptic vesicle exocytosis |
| SNARE binding |
| vesicle fusion |
| organelle membrane fusion |
| regulation of synaptic vesicle exocytosis |
| cellular response to calcium ion |
| positive regulation of exocytosis |
| regulation of amine transport |
| regulation of anion transport |
| organelle fusion |
| regulation of response to drug |
| neurotransmitter secretion |
| signal release from synapse |
| regulation of neurotransmitter secretion |
| regulation of synaptic vesicle cycle |
| memory |
| synaptic vesicle cycle |
| vesicle-mediated transport in synapse |
| membrane fusion |
| negative regulation of protein secretion |
| negative regulation of peptide secretion |
| regulation of neurotransmitter transport |
| response to calcium ion |
| positive regulation of cell growth |
| regulation of regulated secretory pathway |
| signal release |
| positive regulation of developmental growth |
| neurotransmitter transport |
| negative regulation of protein transport |
| negative regulation of establishment of protein localization |
| regulation of synaptic plasticity |
| cellular response to metal ion |
| negative regulation of secretion by cell |
| regulation of endocytosis |
| cellular response to inorganic substance |
| regulation of exocytosis |
| negative regulation of secretion |
| developmental maturation |
| learning or memory |
| positive regulation of growth |
| positive regulation of ion transport |
| positive regulation of neuron projection development |
| negative regulation of neurogenesis |
| axon |
| cognition |
| vesicle organization |
| negative regulation of nervous system development |
| neuron projection |
| regulation of developmental growth |
| negative regulation of cell development |
| glutamatergic synapse |
| regulation of neurotransmitter levels |
| positive regulation of neuron differentiation |
| response to metal ion |
| neuronal cell body |
| negative regulation of organelle organization |
| positive regulation of cell projection organization |
| positive regulation of secretion by cell |
| regulation of cell growth |
| endomembrane system organization |
| anterograde trans-synaptic signaling |
| dendrite |
| chemical synaptic transmission |
| positive regulation of secretion |
| trans-synaptic signaling |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| synaptic signaling |
| regulation of protein secretion |
| positive regulation of neurogenesis |
| negative regulation of transport |
| protein heterodimerization activity |
| regulation of cell morphogenesis |
| regulation of peptide secretion |
| regulation of neuron projection development |
| response to inorganic substance |
| positive regulation of nervous system development |
| positive regulation of cell development |
| cell junction |
| regulation of vesicle-mediated transport |
| behavior |
| regulation of neuron differentiation |
| regulation of growth |
| intracellular membrane-bounded organelle |
| regulation of plasma membrane bounded cell projection organization |
| perinuclear region of cytoplasm |
| regulation of ion transport |
| regulated exocytosis |
| negative regulation of cellular component organization |
| regulation of protein transport |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| calcium ion binding |
| regulation of peptide transport |
| brain development |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| head development |
| exocytosis |
| regulation of secretion |
| regulation of neurogenesis |
| membrane organization |
| protein homodimerization activity |
| regulation of cellular localization |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| positive regulation of cell differentiation |
| central nervous system development |
| positive regulation of transport |
| secretion by cell |
| regulation of protein localization |
| export from cell |
| regulation of anatomical structure morphogenesis |
| cell-cell signaling |
| secretion |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| regulation of organelle organization |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| nervous system process |
| generation of neurons |
| neurogenesis |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
| establishment of localization in cell |
| regulation of transport |
| vesicle-mediated transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| CI-1040 9.5μM R08 exp472 | -1.95 |
| Quinacrine 2.5μM R03 exp146 | -1.9 |
| Senexin-A 25μM R07 exp400 | -1.86 |
| Resveratrol 16μM R03 exp147 | -1.74 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.5 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15528
- Expression level (log2 read counts): -4.43
Expression Distribution
SYT4 Expression in NALM6 Cells: -4.43
