TAAR1
Gene Information
- Official Symbol: TAAR1
- Official Name: trace amine associated receptor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 134864
- UniProt: Q96RJ0
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Receptor for trace amines, including beta- phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase. {ECO:0000269|PubMed:15718104}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 17967
- Expression level (log2 read counts): -7.68
TAAR1 Expression in NALM6 Cells: -7.68
