TBC1D10C

Entrez Summary: N/A
UniProt Summary: Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras. {ECO:0000269|PubMed:17230191}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Calcipotriol 5μM R08 exp464	-1.75
Dimethyloxaloylglycine 11μM R07 exp314	1.76

filopodium membrane
ficolin-1-rich granule membrane
regulation of cilium assembly
retrograde transport, endosome to Golgi
activation of GTPase activity
cytosolic transport
Rab GTPase binding
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
regulation of organelle assembly
endosomal transport
GTPase activator activity
positive regulation of GTPase activity
regulation of GTPase activity
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
regulation of plasma membrane bounded cell projection organization
regulated exocytosis
regulation of cell projection organization
leukocyte mediated immunity
positive regulation of hydrolase activity
exocytosis
leukocyte activation
regulation of cellular component biogenesis
intracellular protein transport
secretion by cell
export from cell
cell activation
immune effector process
secretion
regulation of hydrolase activity