TBX15

Gene Information

Official Symbol: TBX15
Official Name: T-box transcription factor 15
Aliases and Previous Symbols: N/A
Entrez ID: 6913
UniProt: Q96SF7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene belongs to the T-box family of genes, which encode a phylogenetically conserved family of transcription factors that regulate a variety of developmental processes. All these genes contain a common T-box DNA-binding domain. Mutations in this gene are associated with Cousin syndrome.[provided by RefSeq, Oct 2009].
UniProt Summary: Probable transcriptional regulator involved in the development of the skeleton of the limb, vertebral column and head. Acts by controlling the number of mesenchymal precursor cells and chondrocytes (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16158
Expression level (log2 read counts): -2.17

Expression Distribution

Tle3-Aes complex
embryonic cranial skeleton morphogenesis
RNA polymerase II activating transcription factor binding
cranial skeletal system development
cell fate specification
embryonic skeletal system morphogenesis
embryonic skeletal system development
skeletal system morphogenesis
DNA-binding transcription repressor activity, RNA polymerase II-specific
cell fate commitment
embryonic organ morphogenesis
RNA polymerase II regulatory region sequence-specific DNA binding
embryonic organ development
DNA-binding transcription activator activity, RNA polymerase II-specific
protein heterodimerization activity
skeletal system development
RNA polymerase II proximal promoter sequence-specific DNA binding
embryonic morphogenesis
chordate embryonic development
embryo development ending in birth or egg hatching
negative regulation of transcription by RNA polymerase II
protein homodimerization activity
animal organ morphogenesis
embryo development
negative regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
positive regulation of transcription, DNA-templated
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
negative regulation of gene expression
positive regulation of RNA metabolic process