TBX18

Gene Information

Official Symbol: TBX18
Official Name: T-box transcription factor 18
Aliases and Previous Symbols: N/A
Entrez ID: 9096
UniProt: O95935
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This genes codes for a member of an evolutionarily conserved family of transcription factors that plays a crucial role in embryonic development. The family is characterized by the presence of the DNA-binding T-box domain and is divided into five sub-families based on sequence conservation in this domain. The encoded protein belongs to the vertebrate specific Tbx1 sub-family. The protein acts as a transcriptional repressor by antagonizing transcriptional activators in the T-box family. The protein forms homo- or heterodimers with other transcription factors of the T-box family or other transcription factors. [provided by RefSeq, Nov 2012].
UniProt Summary: Acts as transcriptional repressor involved in developmental processes of a variety of tissues and organs, including the heart and coronary vessels, the ureter and the vertebral column. Required for embryonic development of the sino atrial node (SAN) head area. {ECO:0000250|UniProtKB:Q9EPZ6, ECO:0000269|PubMed:26235987}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15014
Expression level (log2 read counts): -2.17

Expression Distribution

regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation
negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation
Tle3-Aes complex
RNA polymerase II activating transcription factor binding
somitogenesis
transcription regulatory region sequence-specific DNA binding
somite development
cell fate specification
segmentation
regulation of embryonic development
morphogenesis of embryonic epithelium
negative regulation of canonical Wnt signaling pathway
negative regulation of Wnt signaling pathway
anterior/posterior pattern specification
DNA-binding transcription repressor activity, RNA polymerase II-specific
cell fate commitment
regulation of canonical Wnt signaling pathway
renal system development
RNA polymerase II regulatory region sequence-specific DNA binding
urogenital system development
regionalization
regulation of Wnt signaling pathway
morphogenesis of an epithelium
pattern specification process
DNA-binding transcription activator activity, RNA polymerase II-specific
protein heterodimerization activity
tissue morphogenesis
embryonic morphogenesis
chordate embryonic development
embryo development ending in birth or egg hatching
negative regulation of transcription by RNA polymerase II
protein homodimerization activity
anatomical structure formation involved in morphogenesis
negative regulation of developmental process
embryo development
regulation of anatomical structure morphogenesis
epithelium development
negative regulation of transcription, DNA-templated
negative regulation of multicellular organismal process
positive regulation of transcription by RNA polymerase II