TBX4

Entrez Summary: This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human homolog of mouse Tbx4, which is closely linked to Tbx2 on mouse chromosome 11. Similarly this gene, like TBX2, maps to human chromosome 17. Expression studies in mouse and chicken show that Tbx4 is expressed in developing hindlimb, but not in forelimb buds, suggesting a role for this gene in regulating limb development and specification of limb identity. [provided by RefSeq, Jul 2008].
UniProt Summary: Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

RNA polymerase II activating transcription factor binding
cell fate specification
embryonic limb morphogenesis
embryonic appendage morphogenesis
limb morphogenesis
appendage morphogenesis
lung development
respiratory tube development
limb development
appendage development
respiratory system development
skeletal system morphogenesis
cell fate commitment
RNA polymerase II regulatory region sequence-specific DNA binding
angiogenesis
blood vessel morphogenesis
morphogenesis of an epithelium
DNA-binding transcription activator activity, RNA polymerase II-specific
blood vessel development
skeletal system development
vasculature development
cardiovascular system development
tissue morphogenesis
embryonic morphogenesis
tube morphogenesis
DNA-binding transcription factor activity
tube development
negative regulation of transcription by RNA polymerase II
circulatory system development
anatomical structure formation involved in morphogenesis
animal organ morphogenesis
embryo development
epithelium development
negative regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process