TBXA2R [The Human Chemical-Genetic Interaction Map Project]

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======= TBXA2R =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TBXA2R
  * **<color #00a2e8>Official Name</color>**: thromboxane A2 receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6915|6915]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P21731|P21731]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TBXA2R&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TBXA2R|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/188070|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase. {ECO:0000269|PubMed:8613548}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|thromboxane A2 signaling pathway|
|thromboxane A2 receptor activity|
|negative regulation of cell migration involved in sprouting angiogenesis|
|negative regulation of sprouting angiogenesis|
|positive regulation of hemostasis|
|positive regulation of blood coagulation|
|positive regulation of coagulation|
|positive regulation of vasoconstriction|
|positive regulation of smooth muscle contraction|
|negative regulation of blood vessel endothelial cell migration|
|positive regulation of blood pressure|
|response to testosterone|
|regulation of cell migration involved in sprouting angiogenesis|
|positive regulation of muscle contraction|
|negative regulation of endothelial cell migration|
|positive regulation of wound healing|
|regulation of vasoconstriction|
|regulation of smooth muscle contraction|
|positive regulation of response to wounding|
|negative regulation of epithelial cell migration|
|regulation of sprouting angiogenesis|
|positive regulation of blood circulation|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of coagulation|
|acrosomal vesicle|
|regulation of blood vessel endothelial cell migration|
|negative regulation of angiogenesis|
|guanyl-nucleotide exchange factor activity|
|negative regulation of blood vessel morphogenesis|
|negative regulation of vasculature development|
|response to ethanol|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|regulation of wound healing|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|regulation of tube size|
|cAMP-mediated signaling|
|regulation of endothelial cell migration|
|regulation of muscle contraction|
|positive regulation of angiogenesis|
|regulation of response to wounding|
|vascular process in circulatory system|
|cyclic-nucleotide-mediated signaling|
|regulation of blood pressure|
|positive regulation of vasculature development|
|cellular response to lipopolysaccharide|
|cellular response to molecule of bacterial origin|
|response to ketone|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|response to nutrient|
|cellular response to biotic stimulus|
|regulation of epithelial cell migration|
|response to alcohol|
|regulation of muscle system process|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|negative regulation of cell migration|
|negative regulation of cell motility|
|positive regulation of cytosolic calcium ion concentration|
|regulation of angiogenesis|
|regulation of blood circulation|
|response to antibiotic|
|negative regulation of cellular component movement|
|response to lipopolysaccharide|
|regulation of vasculature development|
|negative regulation of locomotion|
|response to molecule of bacterial origin|
|regulation of cytosolic calcium ion concentration|
|second-messenger-mediated signaling|
|blood circulation|
|circulatory system process|
|nuclear speck|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|regulation of body fluid levels|
|response to nutrient levels|
|inflammatory response|
|response to toxic substance|
|regulation of anatomical structure size|
|cellular response to lipid|
|response to extracellular stimulus|
|cellular metal ion homeostasis|
|regulation of system process|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|response to bacterium|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|regulation of cell migration|
|response to lipid|
|cellular homeostasis|
|response to hormone|
|regulation of cell motility|
|response to organic cyclic compound|
|negative regulation of developmental process|
|regulation of locomotion|
|regulation of cellular component movement|
|response to drug|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|chemical homeostasis|
|negative regulation of multicellular organismal process|
|response to other organism|
|response to external biotic stimulus|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|integral component of plasma membrane|
|response to endogenous stimulus|
|regulation of response to stress|
|response to oxygen-containing compound|
|homeostatic process|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|-1.77|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|1.7|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11602
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TBXA2R Expression in NALM6 Cells: 4.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>