TBXA2R

Gene Information

Official Symbol: TBXA2R
Official Name: thromboxane A2 receptor
Aliases and Previous Symbols: N/A
Entrez ID: 6915
UniProt: P21731
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
UniProt Summary: Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase. {ECO:0000269|PubMed:8613548}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11602
Expression level (log2 read counts): 4.03

Expression Distribution

Screen	Score
Vinblastine 0.2μM R03 exp108	-1.77
ZLN024 50μM R08 exp538	1.7
WNT3A 44ng/ml R08 exp537	1.74

thromboxane A2 signaling pathway
thromboxane A2 receptor activity
negative regulation of cell migration involved in sprouting angiogenesis
negative regulation of sprouting angiogenesis
positive regulation of hemostasis
positive regulation of blood coagulation
positive regulation of coagulation
positive regulation of vasoconstriction
positive regulation of smooth muscle contraction
negative regulation of blood vessel endothelial cell migration
positive regulation of blood pressure
response to testosterone
regulation of cell migration involved in sprouting angiogenesis
positive regulation of muscle contraction
negative regulation of endothelial cell migration
positive regulation of wound healing
regulation of vasoconstriction
regulation of smooth muscle contraction
positive regulation of response to wounding
negative regulation of epithelial cell migration
regulation of sprouting angiogenesis
positive regulation of blood circulation
regulation of blood coagulation
regulation of hemostasis
regulation of coagulation
acrosomal vesicle
regulation of blood vessel endothelial cell migration
negative regulation of angiogenesis
guanyl-nucleotide exchange factor activity
negative regulation of blood vessel morphogenesis
negative regulation of vasculature development
response to ethanol
adenylate cyclase-activating G protein-coupled receptor signaling pathway
regulation of wound healing
regulation of tube diameter
regulation of blood vessel diameter
regulation of tube size
cAMP-mediated signaling
regulation of endothelial cell migration
regulation of muscle contraction