TCAF1

Gene Information

Official Symbol: TCAF1
Official Name: TRPM8 channel associated factor 1
Aliases and Previous Symbols: N/A
Entrez ID: 9747
UniProt: Q9Y4C2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Positively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration inhibition in a TRPM8-dependent manner. {ECO:0000269|PubMed:25559186}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18531
Expression level (log2 read counts): 5.92

Expression Distribution

Screen	Score
THZ531 0.11μM R07 exp409	1.77
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	2.36

positive regulation of anion channel activity
positive regulation of anion transmembrane transport
regulation of anion channel activity
regulation of anion transmembrane transport
positive regulation of protein targeting to membrane
regulation of protein targeting to membrane
positive regulation of anion transport
regulation of protein targeting
regulation of anion transport
positive regulation of ion transmembrane transporter activity
positive regulation of transporter activity
positive regulation of protein localization to membrane
ion channel binding
positive regulation of intracellular protein transport
positive regulation of ion transmembrane transport
regulation of protein localization to membrane
positive regulation of transmembrane transport
positive regulation of intracellular transport
regulation of intracellular protein transport
regulation of ion transmembrane transporter activity
negative regulation of cell migration
regulation of transmembrane transporter activity
negative regulation of cell motility
positive regulation of ion transport
regulation of transporter activity
negative regulation of cellular component movement
negative regulation of locomotion
positive regulation of cellular protein localization
regulation of intracellular transport
positive regulation of protein transport
positive regulation of establishment of protein localization
regulation of ion transmembrane transport
regulation of cellular protein localization
regulation of transmembrane transport
regulation of ion transport
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
regulation of cell migration
regulation of cell motility