TCIRG1 [The Human Chemical-Genetic Interaction Map Project]

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======= TCIRG1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TCIRG1
  * **<color #00a2e8>Official Name</color>**: T cell immune regulator 1, ATPase H+ transporting V0 subunit a3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10312|10312]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13488|Q13488]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TCIRG1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TCIRG1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604592|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a subunit of a large protein complex known as a vacuolar H+-ATPase (V-ATPase). The protein complex acts as a pump to move protons across the membrane. This movement of protons helps regulate the pH of cells and their surrounding environment. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Alternative splicing results in multiple transcript variants. Mutations in this gene are associated with infantile malignant osteopetrosis. [provided by RefSeq, May 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Part of the proton channel of V-ATPases (By similarity). Seems to be directly involved in T-cell activation. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|V ATPase I|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dentin mineralization|
|response to silver ion|
|memory T cell activation|
|T-helper 1 cell activation|
|osteoclast proliferation|
|vacuolar proton-transporting V-type ATPase, V0 domain|
|hematopoietic stem cell homeostasis|
|protein catabolic process in the vacuole|
|tooth eruption|
|dentinogenesis|
|interferon-gamma secretion|
|enamel mineralization|
|optic nerve development|
|vacuolar proton-transporting V-type ATPase complex|
|tooth mineralization|
|interferon-gamma production|
|vacuolar acidification|
|regulation of proton transport|
|amelogenesis|
|proton-transporting ATPase activity, rotational mechanism|
|bone resorption|
|phagosome acidification|
|T cell homeostasis|
|transferrin transport|
|CD4-positive, alpha-beta T cell activation|
|transporter activity|
|phagosome maturation|
|osteoclast differentiation|
|intracellular pH reduction|
|bone remodeling|
|pH reduction|
|cytokine secretion|
|cranial nerve development|
|cellular defense response|
|lymphocyte homeostasis|
|alpha-beta T cell activation|
|ficolin-1-rich granule membrane|
|leukocyte homeostasis|
|iron ion transport|
|phagocytic vesicle membrane|
|nerve development|
|ATPase binding|
|odontogenesis of dentin-containing tooth|
|regulation of intracellular pH|
|insulin receptor signaling pathway|
|regulation of cellular pH|
|biomineral tissue development|
|biomineralization|
|leukocyte proliferation|
|regulation of pH|
|tissue remodeling|
|B cell differentiation|
|cellular monovalent inorganic cation homeostasis|
|myeloid leukocyte differentiation|
|regulation of osteoblast differentiation|
|odontogenesis|
|transition metal ion transport|
|late endosome|
|T cell differentiation|
|monovalent inorganic cation homeostasis|
|retina development in camera-type eye|
|proton transmembrane transport|
|cytokine production|
|B cell activation|
|immunoglobulin production|
|protein secretion|
|establishment of protein localization to extracellular region|
|macroautophagy|
|cellular response to insulin stimulus|
|protein localization to extracellular region|
|peptide secretion|
|regulation of insulin secretion|
|production of molecular mediator of immune response|
|regulation of ossification|
|tissue homeostasis|
|homeostasis of number of cells|
|immunoglobulin mediated immune response|
|B cell mediated immunity|
|regulation of peptide hormone secretion|
|endosome membrane|
|myeloid cell differentiation|
|response to insulin|
|T cell activation|
|lymphocyte differentiation|
|process utilizing autophagic mechanism|
|ossification|
|autophagy|
|lymphocyte mediated immunity|
|cellular response to peptide hormone stimulus|
|regulation of hormone secretion|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|lysosomal membrane|
|camera-type eye development|
|apical plasma membrane|
|multicellular organismal homeostasis|
|cellular response to peptide|
|leukocyte differentiation|
|regulation of cation transmembrane transport|
|anatomical structure homeostasis|
|eye development|
|visual system development|
|sensory system development|
|response to metal ion|
|lymphocyte activation|
|response to peptide hormone|
|monovalent inorganic cation transport|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|response to peptide|
|regulation of ion transmembrane transport|
|neutrophil degranulation|
|divalent inorganic cation homeostasis|
|neutrophil activation involved in immune response|
|regulation of peptide secretion|
|inflammatory response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|response to inorganic substance|
|regulation of hormone levels|
|sensory organ development|
|cell population proliferation|
|hemopoiesis|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|myeloid leukocyte activation|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|cation transmembrane transport|
|cellular protein catabolic process|
|metal ion homeostasis|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|immune system development|
|cellular response to nitrogen compound|
|protein catabolic process|
|regulation of ion transport|
|regulated exocytosis|
|regulation of protein transport|
|cation homeostasis|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|leukocyte mediated immunity|
|ion homeostasis|
|exocytosis|
|regulation of secretion|
|cation transport|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|cellular macromolecule catabolic process|
|response to hormone|
|positive regulation of cell population proliferation|
|apoptotic process|
|leukocyte activation|
|ion transmembrane transport|
|animal organ morphogenesis|
|response to organonitrogen compound|
|secretion by cell|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|export from cell|
|macromolecule catabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|organonitrogen compound catabolic process|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|cell death|
|response to cytokine|
|chemical homeostasis|
|secretion|
|cellular response to endogenous stimulus|
|transmembrane transport|
|defense response|
|ion transport|
|integral component of plasma membrane|
|response to endogenous stimulus|
|protein transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|establishment of protein localization|
|regulation of cell population proliferation|
|homeostatic process|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|nitrogen compound transport|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2892
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TCIRG1 Expression in NALM6 Cells: 6.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>