TCL1A

Gene Information

Official Symbol: TCL1A
Official Name: T cell leukemia/lymphoma 1A
Aliases and Previous Symbols: N/A
Entrez ID: 8115
UniProt: P56279
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. {ECO:0000269|PubMed:10716693, ECO:0000269|PubMed:10983986, ECO:0000269|PubMed:11707444, ECO:0000269|PubMed:11839817}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13114
Expression level (log2 read counts): 8.88

Expression Distribution

positive regulation of mitochondrial membrane potential
positive regulation of membrane potential
positive regulation of protein oligomerization
protein serine/threonine kinase activator activity
protein homotrimerization
regulation of protein oligomerization
protein trimerization
regulation of mitochondrial membrane potential
positive regulation of peptidyl-serine phosphorylation
regulation of peptidyl-serine phosphorylation
cellular response to tumor necrosis factor
positive regulation of protein complex assembly
response to tumor necrosis factor
positive regulation of protein serine/threonine kinase activity
protein homooligomerization
regulation of membrane potential
regulation of protein complex assembly
protein kinase binding
regulation of protein serine/threonine kinase activity
protein complex oligomerization
positive regulation of cellular component biogenesis
positive regulation of protein kinase activity
positive regulation of kinase activity
protein-containing complex
positive regulation of transferase activity
regulation of protein kinase activity
regulation of kinase activity
negative regulation of apoptotic process
negative regulation of programmed cell death
positive regulation of cell population proliferation
regulation of cellular component biogenesis
regulation of transferase activity
negative regulation of cell death
cellular response to cytokine stimulus
endoplasmic reticulum
positive regulation of protein phosphorylation
positive regulation of phosphorylation
identical protein binding
response to cytokine
positive regulation of phosphate metabolic process