TCTA

Entrez Summary: N/A
UniProt Summary: May be required for cellular fusion during osteoclastogenesis. {ECO:0000269|PubMed:19560569}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
LLY-283 2.6μM R06 exp290	-1.99
BI-D1870 2μM R04 exp162	1.76

osteoclast fusion
multinuclear osteoclast differentiation
negative regulation of osteoclast differentiation
cell-cell fusion
syncytium formation by plasma membrane fusion
syncytium formation
osteoclast differentiation
negative regulation of myeloid leukocyte differentiation
regulation of osteoclast differentiation
negative regulation of myeloid cell differentiation
negative regulation of leukocyte differentiation
myeloid leukocyte differentiation
regulation of myeloid leukocyte differentiation
negative regulation of hemopoiesis
myeloid cell differentiation
regulation of myeloid cell differentiation
regulation of leukocyte differentiation
leukocyte differentiation
negative regulation of immune system process
regulation of hemopoiesis
hemopoiesis
hematopoietic or lymphoid organ development
immune system development
negative regulation of cell differentiation
molecular function
anatomical structure formation involved in morphogenesis
negative regulation of developmental process
negative regulation of multicellular organismal process
regulation of immune system process
regulation of cell differentiation